6 years younger in 12 weeks.1
This next-generation, skin rejuvenating formula improves the appearance of coarse wrinkles, fine lines, skin tone, and texture. It’s the only growth factor product proven to address sagging skin. Visible results in just 2 weeks. Results continue to improve through 24 weeks of use.1
Colorless, fragrance-free, lightweight finish. For all skin types.
Key Benefits1
- Smooths visible coarse wrinkles and fine lines, with results starting as early as 2 weeks.
- Clinically proven to address sagging skin at week 4.
- Progressive results measured over 24 weeks.
Store at room temperature.
1 Data on file at SkinMedica®.
Ingredients
Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera (Grape) Flower Cell Extract, Pyrus Malus (Apple) Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin

What it is
SkinMedica's growth factor serum
TNS® Advanced+ Serum is SkinMedica's next-generation, skin rejuvenating formula. It improves the appearance of coarse wrinkles, fine lines, skin tone and texture, and SkinMedica says it is the only growth factor product proven to address sagging skin.
It is colorless, fragrance-free and lightweight, for all skin types.

Why it works
Two formulas, one routine step
The bottle has two chambers. TNS®-MR holds the growth factor blend (human fibroblast conditioned media) with a peptide complex. RENESSENSCE (RSC) Advanced is a blend of botanicals, marine extracts and peptides designed to support the growth factors' results.
You take one pump from each and blend them as you apply.
How to use
Morning and evening
- Cleanse and toneStart with a clean, dry face, morning and evening.
- One pump from each sideDispense one pump from each chamber onto your hand and blend the two together.
- Apply, then let it absorbSmooth over the face, and the neck and chest if you like. Let it absorb fully before the rest of your routine. Avoid the eyes.

The CRIS Method
Your Impact step
TNS® Advanced+ Serum is the Impact step in the CRIS Method: the targeted treatment you apply to cleansed, exfoliated skin, before you saturate with moisturizer.
Within Impact, it is the G in GVAPE: growth factors go on first, before vitamins, antioxidants, peptides and extra treatments.
Results
What the studies showed
Results reported by SkinMedica® from its clinical studies (data on file at SkinMedica). The 6-years figure is from a third-party, validated psychometric scale; SkinMedica also reports significant improvement in the appearance of sagging skin, and subjects grew more satisfied with continued use through 24 weeks. Individual results may vary.

SkinMedica
Pair it with Even & Correct™
Even & Correct™ Advanced Brightening Treatment is SkinMedica's daily serum to help target and prevent visible hyperpigmentation. In the CRIS Method, TNS® Advanced+ goes on first, then Even & Correct.
Frequently asked questions
What is TNS® Advanced+ Serum, and who is it for?
A growth factor serum from SkinMedica for all skin types. It targets the look of coarse wrinkles, fine lines, uneven tone and texture, and sagging skin.
Why does it have two pumps?
The bottle has two chambers: TNS®-MR, with the growth factor blend and peptides, and RSC Advanced, with botanicals, marine extracts and peptides. Take one pump from each, blend them in your hand, then apply.
Morning, night, or both?
Both. SkinMedica directs applying it morning and evening, after cleansing and toning.
When will I see results?
SkinMedica reports visible results in coarse wrinkles and fine lines in as little as 2 weeks, with results that keep improving through 24 weeks of use.
Where does it go in my routine?
After you cleanse and exfoliate, and first in your Impact step: growth factors go on before vitamins, antioxidants, peptides and extra treatments. Let it absorb, then moisturize.
Is it fragrance-free?
Yes. It is colorless and fragrance-free, with a lightweight finish.