The Skincare Serum That Started in Space
There are a lot of skincare origin stories.
And then there’s: this ingredient came from a microorganism that spent 18 months on the outside of the International Space Station.
Which, admittedly, gets our attention.
The Aeonia Age Defying Serum from Delavie Sciences is built around a patented ingredient called Bacillus Lysate — technology that grew out of research involving a microorganism exposed to the extremely harsh conditions of space.
Yes, actual space.
But the reason Aeonia is interesting isn’t simply because it gives us an excuse to talk about the International Space Station. It’s what researchers learned from that microorganism afterward - and how those findings translated into an ingredient designed to support some of the biological processes associated with healthier, more resilient-looking skin.
So let’s get into the part that actually matters.
First: What Exactly Is Bacillus Lysate?
Bacillus Lysate is Delavie Sciences’ patented hero ingredient.
Its story starts with a microorganism that spent 18 months on the exterior of the International Space Station, exposed to an environment that is, to put it mildly, not particularly hospitable.
After it returned to Earth, researchers studied the organism’s ability to withstand those extreme conditions. That research eventually contributed to the development of Bacillus Lysate for use in skincare. The technology has since been recognized by the Space Foundation as Certified Space Technology™.
Cool backstory.
But we are not buying skincare based solely on its resume.
The more interesting question is what Bacillus Lysate appears to do in the skin.
This Is Where SIRT1 Comes In
One of the mechanisms researchers have studied with Bacillus Lysate is its effect on SIRT1.
If you’re already deep in the longevity world, that name might sound familiar.
SIRT1 is part of a family of proteins called sirtuins, which are involved in cellular processes associated with stress response, metabolism, repair, and aging.
In testing cited by Delavie, Bacillus Lysate was shown to stimulate SIRT1 activity. It has also demonstrated antioxidant activity against UVA-induced free radicals and increased hyaluronic acid production in skin cells.
In normal-person language?
This isn’t just another ingredient designed to make your skin feel silky for six hours.
The idea is to support some of the systems involved in keeping skin hydrated and resilient while helping it better handle environmental stress.
And that is why Aeonia fits so naturally into a longevity-focused skincare routine.
The Hyaluronic Acid Part Is Pretty Interesting, Too
We all know hyaluronic acid.
It has been put into approximately every hydrating skincare product on earth at this point.
But there’s an important distinction here.
Rather than simply adding hyaluronic acid to the surface of the skin, research on Bacillus Lysate looked at its ability to encourage the skin’s own hyaluronic acid production.
Third-party testing cited by Delavie found an increase in hyaluronic acid production in skin cells of up to 238%.
That matters because hyaluronic acid plays a major role in hydration and that plump, cushioned quality we associate with healthy-looking skin.
And, unsurprisingly, our natural levels don’t stay exactly the same forever.
Rude, but predictable.
So What Does Aeonia Age Defying Serum Actually Do?
This is where we move from the petri dish to your bathroom mirror.
It boosts hydration
This is probably the benefit you’ll notice first.
According to Delavie’s clinical testing, the Aeonia Age Defying Serum increased skin moisture content by 39% after one use.
So while the longevity science is the interesting part of the formula, you don’t have to patiently wait months for your skin to feel different.
Hydrated skin tends to look smoother, plumper, and more luminous almost immediately.
We like instant gratification when it comes with long-term thinking.
It helps improve fine lines and wrinkles
In third-party testing reported by Delavie, the appearance of fine lines and wrinkles improved by up to 53% after 28 days.
That doesn’t mean wrinkles disappear.
We are still on Earth, unfortunately.
But improved hydration combined with support for the skin’s underlying biological processes can help skin look smoother, firmer, and more resilient over time.
It can improve radiance
Aeonia is also designed for dullness and uneven-looking skin.
Third-party testing reported an increase in skin radiance of up to 75% after 14 days, and in Delavie’s 28-day clinical trial, 94% of participants agreed that their skin looked brighter and more even.
This is one of those benefits that’s difficult to describe until you see it.
Not “glittery.”
Not aggressively dewy.
Just healthier-looking skin.
It supports firmer, more resilient-looking skin
In the same 28-day clinical trial, 97% of participants said their skin felt hydrated, firmer, and more resilient. The study included 34 subjects.
Again, we’re talking about improving how the skin looks and feels - not changing facial structure.
But for mature skin, that combination of hydration, elasticity, and resilience is exactly where things get interesting.
And Then There’s Hyperpigmentation
Aeonia isn’t marketed only as a hydration or wrinkle serum.
Delavie has also studied the formula's effect on pathways associated with hyperpigmentation.
Lab testing looked at both tyrosinase activity and melanin production. Tyrosinase is an enzyme involved in melanin formation, which means it plays a role in the development of dark spots and uneven pigmentation.
The Age Defying Serum was shown in Delavie’s testing to inhibit tyrosinase activity and decrease melanin production, supporting its use for improving the appearance of uneven tone and dark spots.
Translation: there’s more happening here than hydration.
Bacillus Lysate Isn’t Working Alone
The formula also includes several ingredients you may already recognize, including:
Tetrahexyldecyl ascorbate — an oil-soluble form of vitamin C used for antioxidant support and brightening.
Sodium hyaluronate — a form of hyaluronic acid that helps attract and retain moisture.
Ferulic acid — an antioxidant commonly used to help combat oxidative stress.
Resveratrol — another antioxidant with a particularly interesting reputation in longevity research.
Vitamin E — included for antioxidant and skin-conditioning support.
So while Bacillus Lysate is definitely the headline ingredient, it’s sitting inside a pretty thoughtful antioxidant and hydration formula.
Which we prefer to a product where one exciting ingredient is surrounded by… not much else.
Where Does Aeonia Fit Into the CRIS Method?
Very easily.
C — Cleanse
Start with clean skin.
Remove makeup, SPF, oil, and the general evidence that you existed in the outside world that day.
R — Remove
Next comes exfoliation.
Use the exfoliation step appropriate for your skin type and tolerance. This helps clear away excess dead skin cells so your treatment products can be applied to properly prepped skin.
I — Impact
This is where Aeonia goes.
After cleansing and exfoliating, apply one pump of Aeonia Age Defying Serum to the face.
This is your high-impact treatment step - where we want targeted ingredients directly against prepared skin.
Delavie recommends using the serum morning and evening.
S — Saturate
Follow with your additional serums if you use them, then moisturizer.
In the morning, always finish with sunscreen.
Because no matter how interesting your antioxidant serum is, we are not asking it to do SPF’s job.
Who Is Aeonia Best For?
This serum makes the most sense for someone who is starting to think beyond simply treating individual wrinkles.
If your goals include:
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Supporting skin longevity
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Improving hydration
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Softening the appearance of fine lines and wrinkles
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Improving dullness or uneven tone
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Supporting firmness and elasticity
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Building a routine around antioxidant protection
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Addressing visible signs of aging without using an especially aggressive treatment
Aeonia becomes a very compelling option.
It’s particularly interesting for mature skin because so many of its benefits overlap with the changes we tend to see over time: decreased hydration, slower recovery, uneven tone, loss of resilience, and less of that naturally plump quality skin had when we were younger.
When Should You Expect Results?
Some of the hydration benefits can happen relatively quickly.
Delavie reports increased hydration after a single use, and some clinical trial participants experienced greater hydration within about 30 minutes.
The more visible changes take longer.
Based on the brand’s testing:
After one use:
Skin hydration can increase.
Around two weeks:
Radiance may begin to noticeably improve.
Around four weeks:
Changes in fine lines, wrinkles, firmness, resilience, and overall skin quality become more relevant to evaluate.
And this is where skincare expectations matter.
The goal isn’t to find something that makes your skin look completely different tomorrow morning.
The goal is to use ingredients that support your skin consistently enough that, six months from now, you’re glad you started six months ago.
Very different philosophy.
So, Is Aeonia Age Defying Serum Worth It?
Here’s what we find most interesting about Aeonia.
It’s not built around chasing one visible sign of aging.
The formula is looking at hydration, oxidative stress, pigmentation, cellular signaling, and resilience together.
That is much more aligned with how we think about longevity skincare.
Because longevity skincare isn’t really about trying to freeze your face at 35.
It’s about supporting the biological processes that help skin function well for as long as possible — while also, obviously, enjoying the fact that healthy skin tends to look pretty good.
And if the ingredient helping us do that happens to trace its origins back to the International Space Station?
We’ll take it.
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